ParkinsonCanadaV1, Main, Exploration, bibRecord, 002899

Temporal effects of paraquat/maneb on microglial activation and dopamine neuronal loss in older rats

Identifieur interne : 002899 ( Main/Exploration ); précédent : 002898; suivant : 002900

Temporal effects of paraquat/maneb on microglial activation and dopamine neuronal loss in older rats

Auteurs : Martine Saint-Pierre [Canada] ; Marie-Eve Tremblay [Canada] ; Attila Sik [Canada] ; Robert E. Gross [États-Unis] ; Francesca Cicchetti [Canada]

Source :

Journal of neurochemistry [ 0022-3042 ] ; 2006.

RBID : Pascal:06-0350524

Descripteurs français

Pascal (Inist)
- Activation, Dopamine, Modèle animal, Toxine, Animal, Dégénérescence, Neurone dopaminergique, Locus niger, Parkinson maladie, Toxicité, Microscopie électronique, Poumon pathologie, Appareil Golgi, Tyrosine 3-monooxygenase, Rat.

English descriptors

KwdEn :
- Activation, Animal, Animal model, Degeneration, Dopamine, Dopaminergic neuron, Electron microscopy, Golgi apparatus, Locus niger, Lung disease, Parkinson disease, Rat, Toxicity, Toxin, Tyrosine 3-monooxygenase.

Abstract

We investigated the effects of combined systemic exposure to the herbicide paraquat (PQ) and the fungicide maneb (MB) in 6-month-old rats, an animal model of Parkinson's disease resulting from environmental toxin exposure. Following two doses of PQ (10 mg/kg) and MB (30 mg/kg), 52% of animals developed fatal lung injury. Examination of the remaining animals showed degeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta 6 weeks, but not 4 weeks, following PQ/MB. In contrast, microglial activation was observed at 4 weeks, but had abated by 6 weeks. Compared with our previous findings in younger rats, these results suggest increased susceptibility of older animals to lung and brain toxicity from PQ/MB exposure. Microglial activation preceded, and therefore likely contributed to, DA neurodegeneration. Further, electron microscopy revealed an abnormal appearance of the Golgi apparatus at 4 weeks that was confirmed using double immunostaining for tyrosine hydroxylase and Golgi. This suggests that PQ/MB causes protein processing dysfunction in nigral DA neurons that may be either a direct effect of PQ/MB or the result of microglial activation.

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">We investigated the effects of combined systemic exposure to the herbicide paraquat (PQ) and the fungicide maneb (MB) in 6-month-old rats, an animal model of Parkinson's disease resulting from environmental toxin exposure. Following two doses of PQ (10 mg/kg) and MB (30 mg/kg), 52% of animals developed fatal lung injury. Examination of the remaining animals showed degeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta 6 weeks, but not 4 weeks, following PQ/MB. In contrast, microglial activation was observed at 4 weeks, but had abated by 6 weeks. Compared with our previous findings in younger rats, these results suggest increased susceptibility of older animals to lung and brain toxicity from PQ/MB exposure. Microglial activation preceded, and therefore likely contributed to, DA neurodegeneration. Further, electron microscopy revealed an abnormal appearance of the Golgi apparatus at 4 weeks that was confirmed using double immunostaining for tyrosine hydroxylase and Golgi. This suggests that PQ/MB causes protein processing dysfunction in nigral DA neurons that may be either a direct effect of PQ/MB or the result of microglial activation.</div>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Temporal effects of paraquat/maneb on microglial activation and dopamine neuronal loss in older rats

Temporal effects of paraquat/maneb on microglial activation and dopamine neuronal loss in older rats

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri